Biomarkers and the Development of Acute and Chronic Diseases
The focus of this program is the utility of biomarkers that predict the development of chronic diseases, particularly cardiovascular diseases and type 2 diabetes mellitus.
Research in this program is focused on the metabolic and cardiovascular outcomes in the population setting. The population samples that will contribute to this project include: Predictive Health Initiative at Emory (600 persons aged 18-80 years with frozen aliquots and DNA isolation), Emory Cardiovascular Genetic Database (1000 persons with frozen aliquots and DNA isolation), Kaiser Georgia Database (300,000 participants with electronic database), the Emory-Madras Diabetes Research Foundation Global Diabetes studies (140,000 participants in electronic database, 160,000 people in the new All India cohort, and detailed characterization of 7,000 people as part of a diabetes prevention trial), the Guatemala longitudinal study, the Peking University/China cohort studies (n=160,000, and a new three generational study of 260,000 women). These projects provide a unique opportunity to study biomarkers and genetic markers of disease risk, and the role of nutrition in large population-based contexts. The population samples provide ethnic and racial diversity (black, white, Hispanics, South Asian) and outcomes related to the development of heart disease and abnormal glucose levels. In addition, in collaboration with CDC scientists, opportunities exist for analysis of national survey data (NHANES, NHIS, BRFSS). The training program will focus on the interface of skills needed to undertake research with a laboratory emphasis in the population setting.